Lumida
/SYRE
⌘K
Spyre Therapeutics Inc

Spyre Therapeutics Inc

SYRE
$90.60USD+2.13%+1.89 today

MARKET CAP

8.0B

P/E (TTM)

FWD P/E

DAY RANGE

$88 – $91

52W RANGE

$15
$110

AI Summary

Stalk
Sell NowMedium

SYRE has broken decisively below its 9-, 20-day EMAs and 50-day SMA, shifting into a corrective/distribution phase. Short-term momentum remains negative, with price extended below declining EMAs and oversold RSI triggering temporary relief risk but no sustained stabilization. Medium-term bias is firmly bearish, favoring execution on rallies into the dynamic resistance zone around the 97–100 EMA area. Sell Now is recommended to capture further downside with rejection at EMAs.

  • Multiple analysts maintain Buy ratings with $120–$140 targets
  • Launched SPY772 Phase 2 SKYLIGHT trial targeting Hidradenitis Suppurativa
  • Weak profitability factors highlight margin and return challenges
Full analysis →
Insider Trades24 trades
DateSideTickerInsiderRoleSharesPriceMkt Cap52W High52W LowValue% ChgRuleAI View
Aug 3, 2026SellSYREScott L BurrowsChief Financial Officer15,000$55.03$8.0B-17.77%+524.61%$825.5K+0.00%10b5-1Buy Now
Aug 3, 2026SellSYRECameron TurtleChief Executive Officer15,000$95.51$8.0B-17.77%+524.61%$1.4M-0.52%10b5-1Buy Now
Jul 1, 2026SellSYREScott L BurrowsChief Financial Officer15,000$51.12$8.0B-17.77%+524.61%$766.8K+0.00%10b5-1Buy Now
Jul 1, 2026SellSYRESheldon SloanChief Medical Officer16,668$57.58$8.0B-17.77%+524.61%$959.7K+0.00%10b5-1Buy Now
Jul 1, 2026SellSYRECameron TurtleChief Executive Officer15,000$87.69$8.0B-17.77%+524.61%$1.3M-0.85%10b5-1Buy Now
Jun 25, 2026SellSYREScott L BurrowsChief Financial Officer30,000$50.82$8.0B-17.77%+524.61%$1.5M+0.00%Buy Now
Jun 3, 2026SellSYRESheldon SloanChief Medical Officer16,666$51.23$8.0B-17.77%+524.61%$853.8K+0.00%10b5-1Buy Now
Jun 1, 2026SellSYREScott L BurrowsChief Financial Officer15,000$42.78$8.0B-17.77%+524.61%$641.7K+0.00%10b5-1Buy Now
Jun 1, 2026SellSYRECameron TurtleChief Executive Officer15,000$70.43$8.0B-17.77%+524.61%$1.1M-0.82%10b5-1Buy Now
May 1, 2026SellSYRECameron TurtleChief Executive Officer15,000$71.37$8.0B-17.77%+524.61%$1.1M-0.40%10b5-1Buy Now
May 1, 2026SellSYREScott L BurrowsChief Financial Officer25,000$42.94$8.0B-17.77%+524.61%$1.1M+0.00%10b5-1Buy Now
May 1, 2026SellSYRESheldon SloanChief Medical Officer156,666$49.48$8.0B-17.77%+524.61%$7.8M+0.00%10b5-1Buy Now
Apr 1, 2026SellSYREScott L BurrowsChief Financial Officer15,000$31.92$8.0B-17.77%+524.61%$478.8K+0.00%10b5-1Buy Now
Apr 1, 2026SellSYRESheldon SloanChief Medical Officer15,916$35.83$8.0B-17.77%+524.61%$570.3K+0.00%10b5-1Buy Now
Apr 1, 2026SellSYRECameron TurtleChief Executive Officer15,000$49.33$8.0B-17.77%+524.61%$739.9K-1.18%10b5-1Buy Now
Mar 3, 2026SellSYREScott L BurrowsChief Financial Officer5,000$27.57$8.0B-17.77%+524.61%$137.9K+0.00%10b5-1Buy Now
Mar 2, 2026SellSYRECameron TurtleChief Executive Officer15,000$42.19$8.0B-17.77%+524.61%$632.9K-1.15%10b5-1Buy Now
Feb 2, 2026SellSYRECameron TurtleChief Executive Officer15,000$32.80$8.0B-17.77%+524.61%$492.0K-1.12%10b5-1Buy Now
Jan 2, 2026SellSYRECameron TurtleChief Executive Officer15,000$30.68$8.0B-17.77%+524.61%$460.1K-0.74%10b5-1Buy Now
Dec 1, 2025SellSYRECameron TurtleChief Executive Officer15,000$29.02$8.0B-17.77%+524.61%$435.4K-1.08%10b5-1Buy Now
Nov 3, 2025SellSYRECameron TurtleChief Executive Officer45,000$23.33$8.0B-17.77%+524.61%$1.0M-3.07%10b5-1Buy Now
Sep 2, 2025SellSYREScott L BurrowsChief Financial Officer18,428$16.26$8.0B-17.77%+524.61%$299.6K-15.83%Buy Now
Sep 3, 2024SellSYREScott L BurrowsChief Financial Officer18,531$28.17$8.0B-17.77%+524.61%$522.1K-13.73%Buy Now
Feb 15, 2024BuySYRECameron TurtleChief Executive Officer400$9.82$8.0B-17.77%+524.61%$3.9K+0.05%16bBuy Now