/SYRE

Spyre Therapeutics Inc

SYRE

$90.60USD↑+2.13%+1.89 today

MARKET CAP

8.0B

P/E (TTM)

—

FWD P/E

—

DAY RANGE

$88 – $91

52W RANGE

$15

$110

AI Summary

Stalk

Sell NowMedium

SYRE has broken decisively below its 9-, 20-day EMAs and 50-day SMA, shifting into a corrective/distribution phase. Short-term momentum remains negative, with price extended below declining EMAs and oversold RSI triggering temporary relief risk but no sustained stabilization. Medium-term bias is firmly bearish, favoring execution on rallies into the dynamic resistance zone around the 97–100 EMA area. Sell Now is recommended to capture further downside with rejection at EMAs.

↑Multiple analysts maintain Buy ratings with $120–$140 targets
↑Launched SPY772 Phase 2 SKYLIGHT trial targeting Hidradenitis Suppurativa
↓Weak profitability factors highlight margin and return challenges

Full analysis →

Buying

9

institutions

Selling

6

institutions

New Positions

1

this quarter

Filing Period

Q1 2026

latest 13-F

13-F Holdings

Institution↕	Action↕	Shares Held↕	Value↓	Change↕	Chg %↕	Weight↕
BI Blackrock, Inc. Q2 2026	BUY	6.51 M	577.66 M	+985.38 K	+107.4%	0.01%
PA Perceptive Advisors LLC Q2 2026	SELL	4.32 M	383.48 M	+-3.25 M	+0.5%	5.77%
RI Rtw Investments, LP Q2 2026	BUY	4.25 M	377.49 M	+80.00 K	+79.4%	3.22%
JH Janus Henderson Group Plc Q1 2026	BUY	3.31 M	167.17 M	+1.48 M	+179.0%	0.04%
JC Jpmorgan Chase & Co Q2 2026	BUY	1.09 M	98.87 M	+113.73 K	+122.3%	0.01%
WP Woodline Partners LP Q2 2026	SELL	306.05 K	27.17 M	+-225.74 K	+1.3%	0.08%
AC Adar1 Capital Management, LLC Q2 2026	SELL	283.98 K	25.21 M	+-54.34 K	+47.7%	1.16%
MM Millennium Management LLC Q2 2026	BUY	196.71 K	17.46 M	+50.07 K	+136.1%	0.01%
CA Citadel Advisors LLC Q2 2026	BUY	154.80 K	13.74 M	+31.36 K	+120.7%	0.00%
BA Balyasny Asset Management L.P. Q2 2026	BUY	147.04 K	13.05 M	+91.56 K	+366.5%	0.02%
RC Rockefeller Capital Management L.P. Q2 2026	SELL	47.47 K	4.21 M	+-16.54 K	+30.5%	0.01%
AC Aqr Capital Management LLC Q2 2026	BUY	22.94 K	2.04 M	+2.06 K	+93.4%	0.00%
BH Brevan Howard Capital Management LP Q2 2026	BUYNEW	8.29 K	735.81 K	+8.29 K	+0.0%	0.01%
MG Man Group Plc Q2 2026	SELL	7.71 K	684.85 K	+-1.83 K	+42.2%	0.00%
RC Ra Capital Management, L.P. Q2 2026	SELL	0.00	0.00	+-1.62 M	-100.0%	0.00%